Domperidone is only found in individuals that have used or taken this drug. It is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. Before Using. Drug information provided by: IBM Micromedex. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. was carried out to formulate and evaluate Floating dosage form of Domperidone Maleate as a model drug and had a aim that final batch formulation parameters should shows prolong drug release. Development of dosage form depends on chemical nature of the drug/polymers, matrix structure, swelling, domperidone maleate when administered orally is low due to the first pass metabolism in liver, drug delivery through transdermal drug delivery has the ability to deliver the drug directly to systemic circulation by passing the liver and hence increase in bioavailability of the drug. The main aim of this investigation is to develop and evaluate matrix type transdermal drug delivery systems of. Description and Brand Names. Drug information provided by: IBM Micromedex. Descriptions. Domperidone is a medicine that increases the movements or contractions of the stomach and bowel. Domperidone Maleate Drug Information from Drugs.com. Includes Domperidone Maleate side effects, interactions and indications. Domperidone is a medicine available in a number of countries worldwide. A list of US medications equivalent to Domperidone is available on the Drugs.com website. Domperidone, sold under the brand name Motilium among others, is a peripherally selective dopamine D 2 receptor antagonist that was developed by Janssen Pharmaceutica and is used as an antiemetic, gastroprokinetic agent, and galactagogue. Drug-Drug:Ketoconazoleqblood levels and the risk of cardiovascular toxicity and is contraindicated; other azole antifungals , macrolide anti-infectives and proteaseinhibitors may have similar effects.